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Biogeochemistry and inorganic geochemistry as indicators of the paleoenvironment and paleohydrology of the Al-Azraq Basin, Jordan
(2013)
This study investigates the biogeochemical and inorganic geochemical
indicators for past environments and paleohydrology of a high resolution sediment record
from the Al-Azraq Basin, Jordan. The second largest basin in ...
Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
(University of Missouri -- Kansas City, 2018)
The objective of this study was to develop a clear aqueous mixed nanomicellar
formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic
drugs include triamcinolone acetonide (TA), fluocinolonce ...
Effects of Selected Contaminants on the Physical, Chemical, and Geotechnical Properties of Aquifer Solid
(2014)
The primary objective of this study was to investigate the potential effects of hydrocarbons on the geotechnical properties of sand. A series of laboratory experiments were carried out to ascertain the influence of some ...
Novel Polycyclic Benzannulated Indole Scaffolds via Indole Aryne Cycloaddition, Pd (0)-Catalyzed Cross-coupling and ROM/RCM methodologies: Their Applications to Library Development and Drug Discovery
(2014)
Dissertation under the direction of Keith R. Buszek, Ph.D., Professor of Chemistry,
University of Missouri-Kansas City.
Heterocyclic chemistry is one of the most valuable sources of novel compounds with
diverse biological ...
Structural and enzymatic characterization of bacterial cell wall enzymes: focus on penicillin-binding proteins
(2013)
The research presented in this dissertation was aimed at understanding several structural and biochemical features underlying the bacterial cell wall biosynthetic process using statistical, biochemical and analytical tools. ...
Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)
There are twenty standard amino acids which are proteinogenic and can exist in two stereoisomeric forms, D- and L-enantiomers, except for glycine, which is achiral. The D-amino acids are not incorporated in proteins; ...
Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
(2015-08-04)
The objective of this study was to develop a clear, aqueous drug loaded
nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic
drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone ...
Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)
The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, ...
Engineering of Human Acid Phosphatase Enzyme Sensitive Nanomedicine for HIV/AIDS Prevention by Topical Route
(University of Missouri -- Kansas City, 2018)
This study is divided into two aims. Aim #1 focuses on the development and
characterization of tenofovir (TFV) loaded a stimuli sensitive nanomedicine against male to
female HIV/AIDS infection. Aim #2 focus on the ...
Part I: Effect of Nanomicelle Size on Trans-scleral Permeability of Dexamethasone and Part II: Strategies to Minimize Octreotide Acylation during Sustained Release from Biodegradable Polymers
(2015-06-19)
Our primary aim was to determine the effect of nanomicelle size on dexamethasone (DEX) transport across the sclera. Nanomicelles of various sizes were developed and characterized.
Low molecular weight diblock co-polymers, ...
Novel Prodrugs and Self-Assembling Nanocarriers to Improve Drug Delivery
(University of Missouri -- Kansas City, 2018)
PART I: DIPEPTIDE PRODRUG APPROACH TO IMPROVE INTESTINAL
ABSORPTION OF LOPINAVIR
Lopinavir (LPV), a highly potent second-generation HIV-1 protease inhibitor, is
currently indicated in HIV-1 infection. However, poor ...